Dr. Leon DeJournett has more than thirty years of experience working in the intensive care unit (ICU) setting. Dr. DeJournett first became interested in glucose control in the ICU setting in 2007. After performing an extensive review of the literature in this area, he realized that the control methods in use at that time would not be able to provide safe and effective glucose control as they were not capable of keeping up with the highly dynamic glucose versus time curve seen in ICU patients.
Dr. DeJournett then performed an exhaustive review of the literature to determine how the pancreas and liver work in unison with one another to provide tight glucose control in healthy individuals – the results of this review were published in a peer reviewed journal in 2010. By combining knowledge gained from this review and computer coding skills learned in college, he wrote algorithms that mimic the workings of the native pancreas (insulin release) and liver (glucose release). These algorithms form an expert based rule system, which is considered a form of artificial intelligence (AI).
Dr. DeJournett has multiple peer reviewed publications related to the testing of this AI based glucose control software. In 2014 he formed the Ideal Medical Technologies corporation and subsequently led its development efforts of a closed loop glucose control system (artificial pancreas), which has been given the name FUSION. These efforts included simulation testing, animal testing and collaboration with a multi-national corporation that has developed a CE marked continuous glucose monitor designed for use in the ICU setting. He has also developed a collaboration with a multinational corporation that sells IV pump systems to the U.S. and EU markets.
In addition, he has formed a collaborative agreement with a U.S. academic medical center for purposes of performing the future clinical studies of the FUSION system. These clinical studies will be led be one of the worlds foremost authorities on inpatient glucose control. He also led the effort to obtain Breakthrough Medical Device designation status for the FUSION system, which was granted by the FDA to Ideal Medical Technologies in March 2019. Dr. DeJournett led the pre-submission meetings with the FDA in 2019 and 2020. In April 2020, he led the effort to pivot from a slower scheduled rollout of the FUSION device, to an expedited timeline, in order to respond to the COVID pandemic. In March 2021, this work culminated in FDA approval of our IDE application to begin clinical trials of our closed loop glucose control system, which we have named FUSION.
Dr. DeJournett received his medical training at Stanford University Medical Center.
Steven Kane has more than thirty years of experience in the medical device/biotech arena. Mr. Kane served as President and Chief Executive Officer of Patient Safety Technologies, Inc., a publicly traded medical device company.
Earlier in his career, Mr Kane was President and Chief Executive Officer of Protalex, Inc., a publicly traded drug development company, and held executive level sales and marketing positions for Aspect Medical Systems, Pyxis Corporation, Eli Lilly and Company, and Becton, Dickinson & Company.
While at Aspect, as VP of Sales and Field Operations, he was instrumental in growing the company’s sales from under $1 million to a run rate of $48 million in two and a half years, resulting in an initial public offering (IPO) in January 2000 that ultimately led to its market capitalization reaching in excess of $1 billion. At Pyxis, as Eastern Area VP Of Sales he helped position the company for an IPO in 1992 and held increasingly important sales and marketing positions until it was acquired by Cardinal Health Inc. for $920 million.
Jeremy DeJournett serves as the technical lead and acting Chief Technology Officer for Ideal Medical Technologies. He graduated from the North Carolina School of Science and Mathematics in May 2012, and completed a Bachelor’s of Science in Electrical Engineering from the University of Illinois at Urbana-Champaign in May 2018.
While in school, he worked with a NASA funded CubeSat lab through the Satellite Development Organization, and successfully delivered the CubeSail satellite to Rocket Lab in March of 2018. He was responsible for delivering high level technical reports to principal investigators, as well as translating requirements into technical specifications for the embedded software development team that he led. He streamlined the team’s development process by automating toolchain deployment, centralizing documentation, and increasing developer access to technical knowledge. He also actively recruited for the team, building it from 2 active developers in September 2016 to 15 in May 2018.
In parallel to this work, he was key to the development of Ideal Medical Technologies’ technical stack. During the fall of 2015, he completed the first major revision of the FUSION software, which was used to run a preclinical trial at Wake Forest in December 2015. The following summer, he developed the FUSION simulator, which was used to perform large scale combinatorial analysis of the FUSION software, and to demonstrate the efficacy of the control methodologies in both typical and difficult clinical and non-clinical scenarios.
Through winter of 2016 and spring of 2017, he further extended the FUSION simulator to support other glucose controllers that have seen clinical use, which was used to publish a comparative study of the FUSION controller and reference implementations of the competing controllers. He successfully integrated the FUSION controller with the EIRUS CE marked continuous glucose monitor from Getinge, AB, and tested this working prototype in pre-clinical trials in October 2018. This work included fault tolerance analysis, drug delivery verification, and user interface improvements. He has produced all of the system design and technical documentation required for the Investigational Device Exemption application to the FDA, and will lead the effort in transferring the FUSION devices specifications to the contract manufacturer who will be responsible for creating the commercial grade version of the FUSION device.
Mats Wallin is both an engineer (M.Sc.) and a board certified MD (Anesthesiology and Intensive Care), and holds a PhD in Endocrinology. He is an internationally trusted leading expert in medical devices for anesthesia and intensive care and has recently retired from his position as Medical Director at Maquet Critical Care AB (MCC), one of the world’s largest ICU-ventilator suppliers and a subsidiary to Getinge AB. At MCC he was responsible for medical affairs and pre-clinical and clinical research in anesthesia and advanced monitoring enabling two new class II (Flow-i, EIRUS-monitor), and one class III (EIRUS-CVC), products entering the market. Maquet’s advanced anesthesia machine - Flow-i is the only anesthesia machine with ventilator performance as an ICU-ventilator and has been successfully used in ICUs during the Covid-19 pandemic. The EIRUS- system is a continuous accurate blood-glucose monitoring system for ICU-patients based on a special CVC with a micro-dialysis membrane and two extra ducts used for the blood glucose monitoring function.
Previously he was a senior consultant at the Department of Anesthesiology and Intensive Care at the Karolinska University Hospital. Mats has more than 30 scientific publications and is still an active researcher with ongoing projects in Europe, Australia and Latin-America.
Mats also has an entrepreneurial background as one of the founders of Medair AB, a patient monitoring company producing small class II monitors for ordinary wards and ambulances. Medair was acquired by Nonin 2006. Today he has more than 14 years of board experience in smaller listed public companies (both as a non-executive director as well as being chairman).