The Dexcom G6 continuous glucose monitoring (CGM) system we are using will provide updated glucose values every 5 minutes to the FUSION systems Artificial Intelligence (AI)-based glucose control software. The AI software takes in this glucose data and based on the current glucose levels correlation to the glucose control range prescribed by the patient’s physician (e.g., 100-140 mg/dL), the current glucose rate of change, and the current weight based infusion rates of insulin and dextrose under the FUSION systems control, adjusts the infusion rates of insulin and/or dextrose (glucose) in order to bring safe and effective glucose control to the ICU patient. By adjusting these infusion rates every 5-10 minutes, the AI software is able to keep up with the very dynamic glucose state of ICU patients, thus avoiding both hypoglycemia and hyperglycemia, while at the same time minimizing glucose variability. Our AI based glucose control software was based on a comprehensive review of mans' natural glucose control system – pancreas (insulin release) and liver (glucose release) – and thus exhibits biomimicry.

The FUSION system does not require knowledge of the current rate of intravenous fluids and enteral feedings being administered to the ICU patient, which makes it easy to use. In fact, ICU nurses will spend no more than 20 minutes a day managing the FUSION system.

We have designed the FUSION system to work in a modular fashion, which means it will be capable of working with other CGM systems in the future, so long as they have been approved by the FDA for use in the ICU setting.